Resident Physician in Anatomic and Clinical Pathology

Hospital of the University of Pennsylvania


Washington University in St. Louis - MD/PhD
Thesis work in Molecular Cell Biology in the lab of Dr. Robert Heuckeroth

Gene-environment interactions in Hirschsprung Disease, a model oligogenic disease

Cornell University

BSc from College of Agriculture and Life Sciences


Lake, J. I., Tusheva, O. A., Graham, B. L. & Heuckeroth, R. O. Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis. The Journal of Clinical Investigation 123, 4875–4887 (2013). DOI 10.1172/JCI69781

Highlighted in Nature Reviews Gastroenterology and Hepatology: Role for nongenetic factors in the development of Hirschsprung disease?

Lake, J. I. & Heuckeroth, R. O. Enteric nervous system development: migration, differentiation, and disease. Am. J. Physiol. Gastrointest. Liver Physiol. 305, G1–G24 (2013). DOI 10.1152/ajpgi.00452.2012

Other Projects:

Data analysis and visualization tools.

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